Stress makes cells suicidal

Chronos: Stress Makes the Clock Tick

There is a clock inside every mammalian cell whose complexity exceeds that of any Swiss watch. Made of genes and proteins linked in mutually controlling feedback loops, the cellular clock regulates both itself and multiple circadian processes, including secretion, protein synthesis, and response to stress. The whole-body clock that governs our sleep–wake cycle and that is entrained by exposure ...

The Stress-Diathesis Model of Suicidal Behaviour

Cytoprotective and suicidal signaling in oxidative stress.

Oxidative stress is an imbalance between pro-oxidants and antioxidants in favor of the pro-oxidants, leading to different responses depending on the level of pro-oxidants achieved and the duration of exposure. In this article, we discuss the cytoprotective or suicidal signaling mechanisms associated with oxidative stress by addressing: (i) the development of an acute and mild pro-oxidant state ...

Suicidal oxidative stress induced by certain antioxidants.

Well known antioxidants-coumarins (7,8-dihydroxy-4-methyl coumarin-DHMC and 7,8-diacetoxy-4-methyl coumarin-DAMC) and flavonoids (quercetin-Q and quercetin penta-acetate-QPA) were investigated for their pro-oxidant effects in two human tumor cell lines. The breast carcinoma cell line (MDA-MB-468) was found to be more sensitive to treatment by the drugs-DAMC, Q and QPA at 10 microM than the glio...

Stress and knowledge of suicidal others as factors in suicidal behavior of high school adolescents.

The purpose of this study was to explore adolescent beliefs concerning the causes of adolescent suicide and to examine the influence that suicidal others have on adolescents' behavior. The researcher asked the following questions: Do students reporting suicidal behavior and those reporting no suicidal behavior give different causes for suicide? Do males and females give different causes for sui...